EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.38 | 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | - |
Plasmodium falciparum | |
3.4.23.38 | 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | - |
Plasmodium falciparum | |
3.4.23.38 | 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | - |
Plasmodium falciparum | |
3.4.23.38 | 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.38 | pepstatin | - |
Plasmodium falciparum | |
3.4.23.39 | 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | - |
Plasmodium falciparum | |
3.4.23.39 | 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | - |
Plasmodium falciparum | |
3.4.23.39 | 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | - |
Plasmodium falciparum | |
3.4.23.39 | 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
3.4.23.39 | pepstatin | - |
Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.38 | Plasmodium falciparum | - |
- |
- |
3.4.23.39 | Plasmodium falciparum | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.23.38 | plasmepsin I | - |
Plasmodium falciparum |
3.4.23.38 | PM I | - |
Plasmodium falciparum |
3.4.23.39 | plasmepsin II | - |
Plasmodium falciparum |
3.4.23.39 | PM II | - |
Plasmodium falciparum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.23.38 | 5 | - |
assay at | Plasmodium falciparum |
3.4.23.39 | 5 | - |
assay at | Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.23.38 | 0.000001 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | pepstatin | |
3.4.23.38 | 0.002 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | |
3.4.23.38 | 0.003 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.38 | 0.003 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | |
3.4.23.38 | 0.004 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | |
3.4.23.38 | 0.022 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | |
3.4.23.38 | 0.022 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | |
3.4.23.38 | 0.023 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | |
3.4.23.38 | 0.023 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | |
3.4.23.38 | 0.024 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium | |
3.4.23.38 | 0.028 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | |
3.4.23.38 | 0.037 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | |
3.4.23.38 | 0.041 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.38 | 0.071 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.39 | 0.0000002 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | pepstatin | |
3.4.23.39 | 0.002 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.39 | 0.002 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | |
3.4.23.39 | 0.005 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | |
3.4.23.39 | 0.005 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | |
3.4.23.39 | 0.017 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | |
3.4.23.39 | 0.018 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | |
3.4.23.39 | 0.019 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | |
3.4.23.39 | 0.02 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | |
3.4.23.39 | 0.024 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.39 | 0.032 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
3.4.23.39 | 0.056 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | |
3.4.23.39 | 0.062 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | |
3.4.23.39 | 0.095 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium |